חומרי טיפול

Quantification of laminin, type III collagen synthesis induced by Acetyl tetrapeptide-3 on fibroblasts. It has been demonstrated that molecules which have an activity on these ECM proteins stimulation, also increase hair follicle size and improve hair anchoring.

fibroblAsts

Type III Collagen

Laminin

stimulAtion of ecm proteins synthesis by fibroblAsts

Untreated Acetyl tetrapeptide-3

Control + Acetyl tetrapeptide-3

Acetyl tetrapeptide-3 stimulates dermal papilla extracellular matrix proteins, and thus has a direct effect on structures surrounding hair follicles.

Collagen VII is a major constituent of the anchoring fibrils and is located in the basement membrane (DEJ) around the papilla. In this experiment, corticoids are used to induce a decrease in the hair papilla cells growth and ECM protein.

QuAntitAtive evAluAtion of collAgen vii

Normal skin (untreated)

Collagen VII

SC

Epidermis

Skin + Corticoïds + Acetyl tetrapeptide-3

DEJ

Dermis

Skin + Corticoïds

Acetyl tetrapeptide-3 provides a repairing effect at the dermal-epidermal junction level, helping hair anchoring.

IMPROVING HAIR FOLLICLE LENGTH

Human hair follicles in anagen phase are isolated from skin biopsys and cultured with or without Acetyl tetrapeptide-3 for 8 days.

Acetyl tetrapeptide-3 improves by 35% the length in comparison with untreated areas after 8 days of treatment.

meAsurement of hAir length

Untreated Acetyl tetrapeptide-3

(0.0006% CapixylTM)